abstract：:Liver hyperplasia was induced in rats by daily administration of methylclofenapate (25 mg/kg by gavage). An increase in the incidence of colchicine-arrested metaphases was observed with peaks occurring at 40 h (1.3%), 64 h (6.4%) and 84 h (6.8%) after the start of treatment. This response contrasted with the much larg...

journal_title：Cancer letters

authors： Bybee A,Styles JA,Beck SL,Blackburn D

更新日期：1990-07-16 00:00:00

abstract：:Susceptibility of hairless inbred S/RV Cri-ba or Bare mice to skin tumor development with suboptimal doses of 7,12-dimethylbenz[a]anthracene (DMBA), DMBA-TPA two stage protocol and two stage promotion using 12-O-tetradecanoylphorbol-13-acetate (TPA) as sub-stage 1 promoter and mezerein (MEZ) or phorbol retinoate aceta...

journal_title：Cancer letters

authors： Bhisey RA,Veturkar PL

更新日期：1990-06-30 00:00:00

abstract：:The human c-myb gene which encodes a DNA binding protein and which is rarely amplified in neoplastic cells was found to be altered in four human glioblastoma cell lines. It exists in multiple copies in 2 out of 4 cases studied. The degree of amplification as determined by densitometry was about 10-fold, a rearrangemen...

journal_title：Cancer letters

authors： Welter C,Henn W,Theisinger B,Fischer H,Zang KD,Blin N

更新日期：1990-06-30 00:00:00

abstract：:Hyperproliferation of rectal epithelium is characteristic of families at high genetic risk for large bowel neoplasia, but has not been well-documented in families of sporadic colorectal cancer patients. This was studied in 119 such first degree relatives and 44 comparison subjects without this family history. All scre...

journal_title：Cancer letters

authors： Rozen P,Fireman Z,Fine N,Chetrit A,Lubin F

更新日期：1990-05-30 00:00:00

abstract：:Samples of human endometrial carcinomas of ranging degree of histological differentiation, and normal endometrial tissues were screened for the presence of single site DNA mutations at codon 12 of the C-K-ras gene using oligonucleotide hybridisation of DNA amplified by the polymerase chain reaction (PCR). Two instance...

journal_title：Cancer letters

authors： Lester DR,Cauchi MN

更新日期：1990-05-15 00:00:00

abstract：:Thioproline (TPRO), an effective nitrite trapping agent in vivo, was examined for its detoxifying ability in rats against N-nitrosodimethylamine (NDMA) and N-nitrosocimetidine (NCIM). When NDMA (37-101.5 mg/kg) was administered with TPRO (532 mg/kg), no influence of TPRO on NDMA-induced lethality and histological resu...

journal_title：Cancer letters

authors： Frank N,Tsuda M,Ohgaki H,Frei E,Kato T,Sato S

更新日期：1990-04-30 00:00:00

abstract：:To be capable of selective killing of tumor cells, the non-selective Pseudomonas aeruginosa exotoxin A must have its cell-binding domain inactivated or removed and then be chemically linked to, or genetically fused with, a specific targeting agent. In the present study, epsilon-NH2 groups of lysine residues of the cel...

journal_title：Cancer letters

authors： Bourdenet S,Doyonnas R,Vacheron MJ,Guinand M,Fasciotto B,Ristic A,Michel G,Cozzone AJ,Durkin JP,Whitfield JF

更新日期：1990-04-20 00:00:00

abstract：:Only physiological levels of melatonin exert an antiproliferative effect on MCF-7 breast cancer cells grown in an anchorage-dependent culture system. We investigated melatonin's effect on the anchorage-independent growth of MCF-7 cells as well as the dose-response characteristics of this indoleamine under clonogenic c...

journal_title：Cancer letters

authors： Cos S,Blask DE

更新日期：1990-04-20 00:00:00

abstract：:Cancer prevention techniques include legislative regulation, chemoprevention, adherence to a "healthful" lifestyle, and specialized medical intervention. Attempts at cancer prevention have possibly avoided a dramatic increase in cancer incidence and mortality due to increasing dependence on the products of the chemica...

journal_title：Cancer letters

authors： Clayson DB

更新日期：1990-04-09 00:00:00

abstract：:The age-standardized mortality rates by sex for cancer of all sites and some specific sites were calculated in the 22 areas of Rosario (Argentina). The rates by area were correlated with education, occupation, housing quality and population density, applying Kendall's tau. Cervical cancer rates showed the strongest co...

journal_title：Cancer letters

authors： Poletto L,Morini JC

更新日期：1990-03-01 00:00:00

abstract：:The promoting potential of oxymetholone (OXM) administration on development of liver cell foci was investigated in male F344 rats previously treated with N-diethylnitrosamine (DEN). One week after a single injection of DEN (100 mg/kg, i.p.), rats were given OXM at a dietary level of 0.2% for the first 4 weeks and then...

journal_title：Cancer letters

authors： Shimoji N,Imaida K,Hasegawa R,Matsuoka C,Uneyama CT,Takahashi M,Hayashi Y

更新日期：1990-02-01 00:00:00

abstract：:Glycyrrhetic acid is an anti-inflammatory agent isolated from licorice root that inhibits 12-O-tetradecanoylphorbol-13-acetate (TPA)-mediated tumor promotion in mouse skin. Although it has been established that glycyrrhetic acid inhibits a number of events induced by the phorbol ester tumor promoter TPA in cultured ce...

journal_title：Cancer letters

authors： O'Brian CA,Ward NE,Vogel VG

更新日期：1990-01-01 00:00:00

abstract：:A 65K protein, known for promoting nucleocytoplasmic mRNA transport in a cell-free system, was previously found in fetal and tumor cells of the rat. The primary objective of this study was to show specificity of immunohistochemical staining for the 65K protein in the livers of rats subjected to a hepatocarcinogenesis ...

journal_title：Cancer letters

authors： Hanausek-Walaszek M,Del Rio M,Adams AK

更新日期：1989-12-01 00:00:00

abstract：:Formation of DNA-adducts by 3-BHA or its metabolites, i.e., tert-butyl-1,4-benzoquinone (TBQ) and 5-methoxy-3-tert-butyl-1,2-benzoquinone (3-TBOQ), as well as DNA-adduct formation by 4-nitroquinoline-N-oxide (4NQO), in rat forestomach were examined by an enzymatic 32P-postlabeling assay. Four DNA-adducts were clearly ...

journal_title：Cancer letters

authors： Saito K,Nakagawa S,Yoshitake A,Miyamoto J,Hirose M,Ito N

更新日期：1989-12-01 00:00:00

abstract：:Experimental data were provided to demonstrate the inhibitory effects of retinoids (retinal, retinoic acid, retinyl acetate and retinyl palmitate) and carotenoids (beta-carotene, lycopene and crocetin) on the growth and development of the C-6 glioma cells inoculated in rats. In the pretreatment experiments, most of th...

journal_title：Cancer letters

authors： Wang CJ,Chou MY,Lin JK

更新日期：1989-11-30 00:00:00

abstract：:The present study was undertaken to determine the kinetics of DNA synthesis and expression of cell cycle dependent proto-oncogenes in response to two types of cell proliferative stimuli in male Wistar rat liver. The peak of DNA synthesis was approximately 24 h after a compensatory cell proliferative stimulus induced b...

journal_title：Cancer letters

authors： Coni P,Bignone FA,Pichiri G,Ledda-Columbano GM,Columbano A,Rao PM,Rajalakshmi S,Sarma DS

更新日期：1989-09-15 00:00:00

abstract：:To determine if the carcinogenic potential of peroxisome proliferators is dependent upon their ability to induce cell proliferation, we have investigated the extent of cell proliferation in the livers of rats fed ciprofibrate, a peroxisome proliferator. Male rats were maintained on a diet containing ciprofibrate (0.02...

journal_title：Cancer letters

authors： Yeldandi AV,Milano M,Subbarao V,Reddy JK,Rao MS

更新日期：1989-09-15 00:00:00

abstract：:The level of GSH in ovarian carcinoma cells which were sensitive and resistant to cisplatin was serially determined following tumor removal from the animals, in addition, activities of GSH-reductase and GSH-S-transferase were assessed. The GSH level in the resistant line (O-342/DDP) was almost twice as high as that in...

journal_title：Cancer letters

authors： Chen G,Frei E,Zeller WJ

更新日期：1989-08-01 00:00:00

abstract：:The cell inactivating effect of cis-dichlorodiammineplatinum(II) in combination with 2-substituted benzaldehyde derivatives was tested using cultured human NHIK 3025 cells. Simultaneous drug combination with benzaldehyde protected cells from cis-DDP-induced cell inactivation in a dose-dependent manner. Substitution wi...

journal_title：Cancer letters

authors： Dornish JM,Pettersen EO

更新日期：1989-07-01 00:00:00

abstract：:When injected into female NMRI mice tumour necrosis factor-alpha (TNF) produced a dose-related weight loss over the first 24 h, which was accompanied by and directly proportional to a decrease in both food and water intake. Body composition analysis after the first 8 h revealed that the weight loss was associated with...

journal_title：Cancer letters

authors： Mahony SM,Tisdale MJ

更新日期：1989-06-01 00:00:00

abstract：:We have investigated the structure of the carbohydrate moiety of the precursors of the cathepsin B-like proteinase (PCBt). The largest precursor has an apparent molecular size (Mr) of 45-47 Kd and it contains 3 N-linked oligosaccharide chains which were Endo beta N acetylglucosaminidase H (Endo H)-resistant forms. On ...

journal_title：Cancer letters

authors： Pagano M,Dalet-Fumeron V,Engler R

更新日期：1989-04-01 00:00:00

abstract：:In the present study, the question of whether the ubiquitous environmental pollutant, 1-nitropyrene (1-NP), can induce gamma-glutamyltranspeptidase (GGT)-positive foci, an early lesion occurring during hepatocarcinogenesis, when given orally to F344 rats was examined. Significant induction of GGT-positive foci was obs...

journal_title：Cancer letters

authors： Denda A,Tsutsumi M,Tsujiuchi T,Eimoto H,Konishi Y,Sato S

更新日期：1989-04-01 00:00:00

abstract：:Retinoic acid alone has no effect on the human breast cancer cell line BT-20 but can amplify the antiproliferative action of interferon-gamma (IFN-gamma). In our system ornithine decarboxylase (ODC) activity correlates well with growth rate; it was investigated whether the antiproliferative effects of IFN-gamma and IF...

journal_title：Cancer letters

authors： Marth C,Kirchebner P,Daxenbichler G

更新日期：1989-01-01 00:00:00

abstract：:Pancreatic adenocarcinoma cells show characteristics of macrophages as phagocytosis and exocytosis. These phagocytic activities can be inhibited in macrophages by antirheumatic drugs, e.g. gold compounds and antimalarials. We have now tested the activity of auranofin and chloroquine to inhibit growth of a pancreatic t...

journal_title：Cancer letters

authors： Zeilhofer HU,Mollenhauer J,Brune K

更新日期：1989-01-01 00:00:00

abstract：:Naturally occurring fecal mutagens, called fecapentaenes, are hypothesized to contribute to large bowel carcinogenesis. To understand health risks it is necessary to relate fecal mutagen concentrations to intestinal pathologies, i.e. colon cancer. However, fast and reliable methods for analysis of stool for fecapentae...

journal_title：Cancer letters

authors： Kleinjans JC,Pluijmen MH,Hageman GJ,Verhagen H

更新日期：1989-01-01 00:00:00

abstract：:In order to study the interaction between cis-diamminedichloroplatinum(II) (CDDP) and representative human DNA in a highly defined manner, alphoid sequence DNA was isolated from two human parental cancer lines (one of head and neck squamous cell origin, SCC-25, and one of breast carcinoma origin, MCF-7) as well as fro...

journal_title：Cancer letters

authors： Chan V,Elliott KE,Herman TS,Teicher BA

更新日期：1988-12-15 00:00:00

abstract：:The effects of trisodium nitrilotriacetate monohydrate (Na3 NTA.H2O) nitrilotriacetic acid (H3NTA) and ammonium chloride (NH4Cl) on two-stage urinary bladder carcinogenesis were examined. Carcinogenesis was initiated by administration of 0.2% N-bis (2-hydroxypropyl)-nitrosamine (DHPN) to male Wistar rats in the drinki...

journal_title：Cancer letters

authors： Kitahori Y,Shimoyama T,Ohshima M,Matsuki H,Hashimoto H,Minami S,Konishi N,Hiasa Y

更新日期：1988-12-01 00:00:00

abstract：:Hepatocyte nodules and hepatocellular carcinomas were induced in male Fischer rats using the resistant hepatocyte model. The immunoreactive cytosolic levels of the heme-binding Z protein (HBP) were reduced by 56% (P less than 0.001; 2-tailed t-test) in early hepatocyte nodules (25 weeks) and hepatocellular carcinomas ...

journal_title：Cancer letters

authors： Roomi MW,Vincent SH,Farber E,Muller-Eberhard U

更新日期：1988-12-01 00:00:00

abstract：:During a follow-up program, breast cancer patients were monitored with serum analyses of mucin-like carcinoma-associated antigen (MCA), CA 15.3 and carcinoembryonic antigen (CEA). Minimum as well as maximum marker values of the individual patterns were selected for further evaluation. Marker levels of risk patients di...

journal_title：Cancer letters

authors： Bieglmayer C,Szepesi T,Neunteufel W

更新日期：1988-11-01 00:00:00

abstract：:Ditercalinium (7-H-pyridocarbazole dimer), a prospective antitumor drug, is a bis-intercalator characterized by a very high affinity towards nucleic acids. Specificity of binding of this drug has been studied using spectroscopy and flow cytometry. The competition experiments between the drug and 4',6-diamidino-2-pheny...

journal_title：Cancer letters

authors： Kapuscinski J,Traganos F,Darzynkiewicz Z

更新日期：1988-11-01 00:00:00

abstract：:The effect of pretreatment of skin of Sencar mice with topically applied tannic acid, quercetin and green tea polyphenols (GTP) on the skin tumor initiating activity of (+/-)-7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE-2) has been evaluated. The animals were pretreated with ...

journal_title：Cancer letters

authors： Khan WA,Wang ZY,Athar M,Bickers DR,Mukhtar H

更新日期：1988-09-01 00:00:00

abstract：:The pyrimido-pyrimidine derivative RA233 was found to selectively kill cultured mouse B16 melanoma cells after prolonged hypoxia. At the optimum cytotoxic concentration (100 microM), RA233 reduced cell clonogenicity by about 80% when administered during long-term hypoxia of 4 days. Comparable cytotoxicity was also evi...

journal_title：Cancer letters

authors： Stackpole CW,Omar RA,Fornabaio DM,Kim YS

更新日期：1988-09-01 00:00:00

abstract：:Time trends and the geographical variation of mortality from gastric cancer in Spain are analysed. The national (1961-1980) and the provincial (1975-1980) crude death rates as well as the age adjusted death rates were calculated using the population census (years 1960 and 1970) and the figures for national and provinc...

journal_title：Cancer letters

authors： Palmeiro R,Senra A,Garcia-Blanco P,Millan J

更新日期：1988-09-01 00:00:00

abstract：:The suitability of a colorimetric [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT)] assay to the determination of cell viability following photoradiation therapy (PRT) of human breast and melanoma cell lines has been examined. Results have been shown to correlate with those obtained using a clonogen...

journal_title：Cancer letters

authors： McHale AP,McHale L

更新日期：1988-08-30 00:00:00

abstract：:Thiourea (TU) fails to enhance the incidence of foci deficient in adenosine-5'-triphosphatase (ATPase) either by initiation or by promotion in a rat liver foci bioassay. To weanling female Sprague-Dawley rats, 3 x 200 or 3 x 500 mg/kg body wt of TU, respectively, were applied for initiation. One week later Clophen A 5...

journal_title：Cancer letters

authors： Oesterle D,Deml E

更新日期：1988-08-30 00:00:00

abstract：:SENCAR mice have been selectively bred for hypersusceptibility to 2-stage chemical skin carcinogenesis. In this study the relative susceptibilities of SENCAR, BALB/c and CD-1 mice to systemic carcinogenesis by N-nitrosohexamethyleneimine (NHEX) were examined. NHEX was administered twice weekly (1 mg/mouse) in corn oil...

journal_title：Cancer letters

authors： Strickland PT,Lijinsky W,Thomas B,Kovatch RM

更新日期：1988-08-15 00:00:00

abstract：:Nitrosamine formation from the reaction of nitroprusside with morpholine was found to be a light-dependent reaction. Maximum nitrosation occurred when the reactants were exposed to UV light (lambda = 275-300 nm). However, considerable nitrosation also occurred with light in the visible spectrum up to 500 nm. No signif...

journal_title：Cancer letters

authors： Cooney RV,Ramseyer J,Ross PD

更新日期：1988-06-15 00:00:00

abstract：:In this study we have compared the anti-proliferative effects of transforming growth factor-beta (TGF-beta), N,N-dimethylformamide (DMF) and retinoic acid (RA) on a moderately-differentiated colon carcinoma cell line (JVC). TGF-beta, DMF and RA inhibited the anchorage-independent growth and induced morphological chang...

journal_title：Cancer letters

authors： Hoosein NM,Brattain DE,McKnight MK,Childress KE,Chakrabarty S,Brattain MG

更新日期：1988-06-15 00:00:00

abstract：:Growing epidemiological evidence points out the carcinogenic hazard of inhaled aflatoxin B1 (AFB1) to the pulmonary system. Metabolism of AFB1 by lung microsomes and its binding to calf thymus DNA are reported for the first time in this paper. In addition, the ability of dietary butylated hydroxyanisole (BHA) to modul...

journal_title：Cancer letters

authors： Allameh A,Saxena M,Raj HG

更新日期：1988-05-01 00:00:00

abstract：:The mucosal glutathione content of the gastrointestinal wall amounted to 50-60% of its concentration in the liver. GSH S-aryltransferase activity (CDNB) was very low in the glandular stomach, colon and rectum amounting to only 5% of liver enzyme activity. There was a marked postpyloric increase in GSH S-aryltransferas...

journal_title：Cancer letters

authors： Siegers CP,Riemann D,Thies E,Younes M

更新日期：1988-05-01 00:00:00